Background:
@EN An animal model was used to study the effects of 85% oxygen pretreatment on the pulmonary toxicity of 100% oxygen exposure in rats. The hypthesis was that pretreatment of rat with 85% oxygen reduced mortality, decrease of compliance and
pathologic
changes.
@ES Methods:
@EN 32 rats wer divided into 4 groups. Group 1 breathed 85% oxygen for 72 hours and exposured to room air for 24 hours. Group 2, 3, 4 breathed 85% oxygen for 72 hours and exposured to 100% oxygen for 24, 48, 72 hours respectively. After the
exposure,
survived rats were intubated through a tracheostomy, and inflation and deflation lung-thorax compliances were calculated. Lung weight per body weight ratios were obtained and the lung specimens got prepared to be examined microscopically.
@ES Results:
@EN Inflation and deflation lung-thorax compliances of group 2, 3, 4 were lower(P<0.05) compared to group 1. Lung weight per body weight ratios of group 2, 3 were increased significantly(P<0.05) compared to group 1, but that of group 4 did not
have any
difference compared to group 1. Pulmonary pathologic findings did not show any significant differences between 4 groups. In group 3, 1 of 8 rats was died and in group 4, 2 of 8 rats were died.
@ES Conclusions:
@EN WE concluded that the pulmonary oxygen toxicity provoked by 100% oxygen exposure was partially prevented by pretreatment of 85% oxygen exposure. And more studies about the method of preventing pulmonary oxygen toxicity should be performed.
(Korean J
Anesthesiol 1996: 30:264~270)
|